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Myeloma is one of those types of blood cancer that patients do not readily identify when they are diagnosed because there is no lump, there is no visible tumor detected on a scan, and its warning signs such as bone pain, fatigue, and repeated infections are very similar to many other illnesses. This type of cancer also underwent a tremendous transformation in terms of treatment options during the last ten years, as a result of which life expectancy improved significantly.
In this guide, we will discuss what myeloma is, what MGUS is, why you have probably heard this term related to the blood test, what the symptoms of myeloma are, and how it is treated now – from chemotherapy to stem cell transplant and even CAR T-cell therapy – with all stages of treatment available in Ghaziabad, at Yashoda Medicity.
Multiple myeloma is a cancer that affects plasma cells, which are a type of white blood cell responsible for producing antibodies that fight infections. In multiple myeloma, there is uncontrolled proliferation of abnormal plasma cells in the bone marrow, which inhibits the production of other blood cells and produces large amounts of a specific, useless antibody, also referred to as the M-protein or paraprotein. The prefix “multiple” is used in the term because this disease occurs in more than one place in the skeletal system.
MGUS stands for Monoclonal Gammopathy of Undetermined Significance, and it is a separate, though related, disorder that you should be well aware of if you have heard about it in a blood test result. MGUS is an abnormal presence of plasma cells and M-proteins in the bloodstream, with numbers insufficient for a diagnosis of myeloma, and no organ damage.
The main thing to remember about MGUS symptoms is that there are virtually none because of the way this disorder is defined – MGUS is diagnosed incidentally during an examination performed for some other purpose that reveals abnormal protein content in the blood. There is a risk of developing multiple myeloma over a long period of time (about 1% per year), which is why MGUS is managed through routine checks but not treatment.
The signs of myeloma may be recalled by the mnemonic “CRAB” – the four major organs affected that together with blood and marrow abnormalities help make the diagnosis of active myeloma, which requires treatment:
Aside from the aforementioned manifestations, other common symptoms of multiple myeloma include recurrent infections (as there is decreased antibody production), generalized fatigue, and in some patients, peripheral neuropathy, or in rare instances spinal cord compression from vertebral fractures.
There have been many changes in the treatment of myeloma in the last ten years because there are different "novel agents," including proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies, which are currently at the core of most treatment regimens and which are used along with steroid therapy and even with stem cell transplantation where possible. It is very important to note that myeloma is considered a chronic disease that requires long-term management with many lines of therapy rather than one-time cure, and this is something to understand at an early stage.
Cytotoxic chemotherapy remains relevant in myeloma therapy, especially high-dose melphalan administration as a conditioning regimen before the autologous stem cell transplant. In terms of induction therapy, current regimens typically consist of a proteasome inhibitor (bortezomib), an immunomodulatory agent (lenalidomide), and dexamethasone, which may be supplemented with a monoclonal antibody in eligible patients, rather than conventional chemotherapy. The type and intensity of the combination are determined by the patient’s general fitness, renal function, cytogenetic risk group, and intention to proceed with a stem cell transplant.
Autologous stem cell transplant, which entails the use of a patient’s previous stem cells collected from him/her in the past, still forms a significant component of treatment in eligible patients after induction therapy.
This approach requires collection (harvesting) of the patient’s own stem cells in advance, administration of high doses of melphalan chemotherapy to destroy any remaining myeloma, and reinfusion of the previously collected stem cells to restore normal bone marrow function. Although this approach alone does not constitute a cure, it significantly improves remission and helps maintain disease control compared with undergoing only induction therapy, and is usually followed by maintenance therapy. Not all patients are ideal candidates for this procedure; various health-related issues come into play here.
CAR T-cell therapy constitutes one of the most important innovations in myeloma treatment in recent times. This therapy collects the patient's own T-cells (which are a kind of immune cell), modifies them in specialized labs so that they recognize and kill the myeloma cells (usually by using an antigen known as BCMA, which is present in myeloma cells), and infuses them back into the patient's body. The therapy is primarily used in cases of relapsed or refractory myeloma, i.e., myeloma that either has relapsed despite multiple treatments or has become resistant to various treatments, and has proved capable of producing profound and even durable responses in carefully selected patients when other treatments have failed. This is a sophisticated, resource-heavy therapy that requires a specialized lab setup, which is precisely what we can offer at our Cell and Gene Therapy Lab.
Should there be any anomaly in your protein levels that a blood test indicates, or do you have bone pains, fatigue, frequent infections, or kidney issues? The early haematological evaluation will help you get a clear picture of what is really happening and ensure all your treatment options remain open. To schedule an appointment with our Hematology-Oncology specialists at Yashoda Medicity, Ghaziabad, call +91 9266610101.
Yashoda Medicity: Yashoda Medicity, Hospital Plot, Shakti Khand 2, Indirapuram, Ghaziabad, Uttar Pradesh - 201014 | Phone: +91 9266610101
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I was suffering from the problem of fluid in my lungs. I consulted many physicians but found no solution. Then I consulted Dr Rajesh Gupta and his team at Yashoda Medicity Indirapuram. He diagnosed my disease accurately by EBUS-TBNA and provided best treatment because of which now I feeling healthy and am ready to hit the gym. I would definitely recommend Dr Rajesh Gupta as one of the best chest specialists in NCR
Excellent consultation with Dr. J. B. Sharma. He was approachable, attentive, and made me feel at ease throughout the appointment. All my concerns were addressed in detail, and the nursing staff was caring and efficient. I would definitely recommend him.
Excellent hospital with caring staff and outstanding medical services. Special thanks to Dr. Vaibhav Saxena for successfully performing my husband's surgery with great expertise and care. We are truly grateful for the excellent treatment and support for doctor Vaibhav saxena 🙏💐
It was a very good experience, I had a cholecystectomy. All the doctors including surgeon, anesthetic, nursing and housekeeping staff were very supportive. I was admitted for 24 hours. Quick and very fast recovery. Under Dr P.K.Dewan, sir is very humble and nice.
A tremendous job has been done by Dr. Amit Sharma. I met with an accident in which the ACL ligament of my left knee was completely torn. I met Dr. Amit Sharma then he analysed the situation and told us about the procedure and the time period to recover from the injury. He has performed a successful surgery. The good thing is the confidence that Dr. Amit Sharma has on his surgery that he didn’t put braces on the knee while other doctors put the braces on for a month and then started Physiotherapy which will take a longer time period to heal from the injury. Dr. Amit Sharma has started the Physiotherapy from the very next day of the surgery and i was discharged in 2 days, and the Physiotherapy is undergoing at my home. It's the 10th day today and I have gained so much confidence in 10 days that I am recovering very fast and in a few weeks I will be able to walk without any support. Thanks to Dr. Amit Sharma, he is really having magical hands, he is very kind in nature, in my regular visits all of my stress went away after talking to him. Again Thank You so much Doctor
I am truly grateful for the wonderful care I received at the hospital. From the moment we entered, the staff treated my father with kindness, respect, and patience. Doctors explained everything clearly and made us feel safe. Nursing staff were always attentive, cooperative and helpful. The rooms were clean, calm, and well-managed. Thank you to the entire team for your dedication and human touch. You don’t just treat illness - you heal with heart. Highly recommend this hospital.
We would like to express our heartfelt gratitude to Dr. Namita dutta nigam and her entire team at yashoda Super Speciality Hospitals, Kaushambi ,for the exceptional care provided to my wife, Mrs. Shilpa tyagi during her emergency delivery.
My wife delivered premature twins (a baby boy and a baby girl) , and this was an emotionally challenging time for our family. Dr Namita dutta nigam handled the entire situation with remarkable expertise, calmness, and compassion. Her timely decisions, clear communication, and reassuring approach gave us confidence throughout the treatment.
We are equally thankful to the entire medical, nursing, and support staff for their professionalism, kindness, and round-the-clock care. Every member of the team treated us with empathy and respect, making us feel supported at every step.
Highly Grateful for Dr. Sudhir Tyagi and Team!
My father recently underwent herinoplastice surgery at Yashoda Super Speciality Hospitals Kaushambi, He took the time to explain the entire procedure and what to expect during recovery. The surgery was highly successful, and my father is recovering well. A special thank you to the nursing staff sanchika; Himanshu khanna; the floor manager; and the entire Yashoda Hospital kaushambi for their excellent care and attentiveness. Truly the best care team in Delhi NCR!
My daughter was admitted to the ICU at Yashoda Super Speciality Hospitals, Kaushambi, and our family went through a very difficult time. We are deeply grateful to the doctors and ICU team for their dedication and care throughout her treatment.
A special thanks to Dr. Girish for his timely guidance and support. We are especially thankful to Dr. Kunal Das (Gastroenterologist) for his accurate diagnosis, clear communication, and compassionate approach. We also appreciate Dr. Shekhar Kashyap for his valuable consultation and reassurance during the treatment.
The ICU doctors, nurses, and support staff worked tirelessly around the clock. They were attentive, professional, and caring, ensuring that every concern was addressed promptly. Their commitment gave us confidence during one of the most challenging periods for our family.
While no family wants to experience an ICU admission, the medical expertise and compassionate care we received at Yashoda Hospital made a significant difference. Thank you to the entire ICU team and the doctors for helping our daughter on her road to recovery. We sincerely appreciate all your efforts and wish the entire team continued success in serving patients with the same dedication.
I had a wonderful experience with my gynecologist Dr Preeti Agarwal throughout my pregnancy in 2019. She is extremely supportive, patient, and compassionate. She explains every concern clearly, making it easy to understand the treatment and next steps. She is also available on call whenever needed, which gave me great reassurance during my pregnancy. Due to this I consulted her again for my second pregnancy in 2026. Her guidance was always practical, honest, and comforting. I truly appreciate her dedication and highly recommend her to anyone looking for a knowledgeable and caring gynecologist.
She is the best gynecologist
I went for a routine gynecological check-up. Dr. Divya Arora is very knowledgeable and patiently addressed all my concerns. She also educated me on general health awareness, which we as women often overlook in this fast-paced world.
Also, almost all the departments are functioning well here.
All experience good, patient treatment was good, satisfied with all the services, nursing staff and doctors team also good and cooperative.
I had an excellent experience at Yashoda Hospital for my mother’s Total Knee Replacement Surgery.
From a clinical perspective, Dr. Amit Sharma and his team were outstanding. Their expertise and professionalism were evident throughout the process, and they did a fantastic job with the surgery and post-operative care.
Beyond the medical treatment, the administrative side was equally impressive. Mr. Varun took complete charge of the Insurance (TPA) and admission process, ensuring everything was seamless and stress-free for our family. His coordination made a significant difference in our overall experience.
We are truly grateful to the entire team for their dedication and care. Highly recommended!
We are extremely grateful to Dr. Gourav Thakral and Dr. Brajesh Koushle and their entire team for my father’s knee surgery. From the first consultation to the surgery and post-operative care, everything was handled with great professionalism, patience, and care. The doctors explained everything clearly, answered all our questions, and gave us confidence throughout the process. The surgery went smoothly and my father’s recovery has been progressing well.
A big thank you to the entire staff for being supportive, responsive, and well-organized. Highly recommended for anyone looking for expert knee treatment and surgery.
I recently had an experience at Yashoda Medicity, Indirapuram, and I must say it is easily one of the most advanced healthcare facilities in the Delhi NCR region. From the moment you walk in, the international-standard infrastructure and the clean, organized environment stand out.
The medical team is exceptional—highly professional, empathetic, and thorough in their diagnosis. I was particularly impressed by their use of cutting-edge technology, including robotic surgery options and a very efficient diagnostic lab. Unlike many large hospitals, the wait times here are well-managed, and the nursing staff is incredibly attentive and polite.
Whether it’s for a routine check-up or specialized treatment, the level of care and transparency regarding the process is reassuring. It truly feels like a world-class institution dedicated to patient well-being. Highly recommended for anyone looking for reliable and high-quality medical care in Ghaziabad.
Mr. Ajeet Kumar Verma from Yashoda Homecare provided satisfactory service of sample collection. Well behaved, humble & polite person
I had really good experience with Yashoda Home Care, the sample collection was very hygienically taken and pain-free, hassle-free. Mr. Ajeet was the phlebotomist.
Had a good experience with Ajeet Kumar Verma from Yashoda Home Care who supported me while I was looking for someone to dress my mom’s stitches. He is very professional and a caring person.
Great support and service by the Home care department. Everyone from Ms Niharika, Mr. Anoop to all the attendants including Mr. Natwar Pandey, Mr Inam and Mr. Ajit, all have been superbly supportive and helpful throughout. God bless you all and highly recommended.
Very good services in home care Yashoda hospital his ish
Caretaker Deepanshu and Jatin and Satish is very good caretaker I have never seen better care takers in my life.
And he is very polite behaviour and friend in nature
Yashoda Super Specialty Hospitals Kaushambi service is very good according other hospital and other home care services
The home care facility provided by the hospital is also good, the staff which was at home was cooperative.
Home care services are Good. Mr. सुनील Sajwan was cooperative and the केयर taker Mrs. Shushila's वर्क has been quite satisfactory.
Had a. Very good experience with Yashoda Homecare, Kaushambi. The staff was very cooperative with excellent on time services. I would like to give a special mention to Mr Sunil Sajwan (Sales) and Sushila ji (PCA) for their quick response and excellent services.
Fully satisfied Mr .Ajeet Kumar Verma service Yashoda home care . vry good
Was great to recieve the best homecare services from yashoda hospital and really impressed with Ms. Niharika's support at the initial phase followed by Mr. Natwar Pandey who was really supportive in taking care of my father basic daily needs.
Thanks for all the support
Dr. Manish Singhal is a highly knowledgeable and experienced doctor. When patients and their families panic on hearing a word like ‘cancer’, Dr. Manish explains everything with such logic, scientific clarity and warmth that their anxiety eases. He has provided excellent treatment for my son’s Burkitt lymphoma. Dr. Manish and his entire team are extremely caring and humble. The overall experience at Yashoda Medicity is very smooth and reassuring.
An Extraordinary Orthopedic Surgeon with Unmatched Expertise
Dr. Amit sharma sir is truly a lifesaver and an outstanding orthopedic specialist.
After my severe accident, my injuries were extensive, and I was in urgent need of expert care. Dr. Amit sharma sir’s incredible skill in assessing and treating my complex fractures and injuries not only saved my life but also set me on the path to a full recovery.
I read somewhere doctors are like God now I believe in that…….thanks 🙏 to Dr. Amit sharma sir who gave me second chances in life….thanks alot sir for everything….you made my treatment possible.
The precision with which you performed multiple procedures, ensuring that my bones, joints, and ligaments were repaired to perfection, was nothing short of miraculous.
You showed great compassion and understanding throughout my treatment you patiently explained each step of the process, made me feel confident in my recovery, and provided me with the best care I could have asked for. Today, I am able to move, walk, and live my life normal again thanks to Dr. Amit sharma sir’s expertise in orthopedic surgery.
Thanks for giving me second chance.
I recently visited Yashoda Medcity Indirapuram for a gynecology appointment, and my experience was excellent. The doctor was very polite, patient, and attentive, taking the time to listen to all my concerns and explain everything clearly. The staff was helpful, and the overall process—from registration to consultation—was smooth and well-organized.
I truly appreciate the professional and caring approach. Highly recommended!
I had my sister’s surgery done at Yashoda Medcity under Dr. Pradeep Diwan, and I’m extremely satisfied with the overall experience. Dr. Diwan is highly skilled, patient, and explains everything clearly, which made me feel very comfortable and confident throughout the process.
The hospital staff was also very supportive — from admission to discharge, everything was handled smoothly. The cleanliness, timely care, and overall hospitality were truly commendable.
Highly recommend Yashoda Medcity and Dr. Pradeep Diwan for anyone looking for expert medical care and a positive hospital experience!
My mother, Veena Tandon, was admitted here with severe chest pain. Dr. Manish Aggarwal and his team handled the situation with great care and professionalism. From quick diagnosis with ECG, echo, and CT angiography to patiently explaining the treatment options, everything was managed very smoothly. The doctor’s expertise and compassionate approach gave us confidence during a stressful time. We are truly grateful for the timely care and support provided. Highly recommend Dr. Manish Aggarwal and the hospital for cardiac treatment.
I had an exceptionally positive experience with Dr. Sumanth Bollu. His expertise in surgical oncology is evident from the very first consultation. He explains every detail with remarkable clarity and patience, making sure the patient and family feel fully informed and reassured.
I must say services in this hospital is top notch. This hospital has very good ambience and nice environment. OPD staff in medicine OPD is very coordinative and supportive. Doctor Vinay Bhat is excellent in his field and treating their patients.
The best hospital with the most amazing doctors!
I had a wonderful experience throughout my pregnancy and delivery. Dr. Samreen Zehra is truly the best gynecologist I’ve ever met — she explained everything clearly and provided not just medical care, but also technical, moral, and emotional support at every step. I always felt I was in the safest and most caring hands.
I underwent a C-section performed by Dr. J. B. Sharma, who is among the top 2% of doctors worldwide. He is incredibly talented, kind, and cooperative. Despite some complications, my delivery was absolutely safe — all thanks to Dr. J. B. Sharma, Dr. Samreen Zehra, and the entire Yashoda Hospital team.
The hospital’s technology and facilities are top-notch, and the staff are extremely supportive and caring. Highly recommend Yashoda Hospital for maternity care — they truly make you feel safe and cared for. 💖
I had consultation with Dr. Ankur Goswami for spine surgery. I had a great and satisfying experience during my wife’s surgery. Hospital staff is very nice and all staff of hospital, especially front office coordinator of orthopedics Ms. Rashmi Chaudhary, is very helpful and cooperative with us before and after treatment.
I am indebted and grateful to Dr. Ankur Goswami who is very experienced.
Wishing all a very happy times always.
Brig Man Mohan Mishra (R)
Greater Noida
Our heartfelt thanks to the entire Hospital, especially Dr Aayush Goyal and his team who performed the CABG surgery on our patient (Sh Arvind Bhatia) with extremely satisfactory results. Personal attention given to our case by the hospital COO, Dr. Sunil Dagar and the total management and the hospital staff, who ensured we were given utmost priority in all respects during the course of the treatment. Special thanks to Dr Asit Khanna for his diagnosis and guidance. Last but not the least, the homecare services provided by the hospital were really good.
Excellent services
Outstanding Results
We wish all the best to the hospital and its team.
Call: +91 9266610101
