Overview of Specialty

The Cell and Gene Therapy Department at Yashoda Medicity is a highly specialized facility dedicated to advanced transfusion medicine, cellular therapies, and genetic interventions. By combining state-of-the-art laboratory technologies with expert clinical care, we provide routine and advanced immunohematology, precision transfusion support, stem cell collection, cellular manipulation, and gene therapy-based treatments.

Our hospital in Vaishali Ghaziabad supports patients requiring life-saving transfusions, stem cell and bone marrow transplants, cellular immunotherapies, and innovative gene-based solutions for hematological, oncological, immunological, and genetic disorders. With a strong emphasis on safety, innovation, and patient-centered care, we serve as a referral hub for complex cases and transplant immunology.

Services Available

Routine and Advanced Immunohematology

  • Automated blood grouping by CAT and solid phase
  • Automated red cell crossmatch
  • Antibody screening, identification, and titration
  • Direct and indirect antiglobulin testing
  • Extended red cell antigen phenotyping
  • Resolution of ABO discrepancies
  • Work-up of DAT-positive samples 
  • Adsorption-elution studies
  • Specialised testing for autoimmune haemolytic anaemia, cold agglutinins, and cryoglobulins
  • Donath Landsteiner test
  • Work-up of individuals on daratumumab therapy

Blood Components (from Whole Blood)

  • Red cells in additive solution
  • Random donor platelet concentrates
  • Fresh frozen plasma
  • Cryoprecipitate
  • Granulocyte concentrates

Blood Components (via Apheresis)

  • Single donor platelet concentrates and plasma
  • Apheresis granulocytes for refractory febrile neutropenia
  • Peripheral blood haematopoietic stem cell (HPC-A) collection for autologous and allogeneic transplants
  • Donor lymphocyte infusion (DLI) to prevent graft rejection
  • Monocyte collection for dendritic cell vaccine preparation
  • Lymphocyte harvest for CAR-T cell therapy

Other Specialised Services

  • Leucodepletion for improved transfusion safety
  • Irradiation of blood products to prevent transfusion-associated GVHD
  • Washing of components for IgA deficiency
  • Therapeutic phlebotomy
  • Intrauterine and exchange transfusion support
  • Precision-guided transfusion using viscoelastic testing (ROTEM/TEG)

Donor Screening for Transfusion-Transmissible Infections

  • Chemiluminescence immunoassay (CLIA) for high-sensitivity viral screening (HBsAg, HIV, HCV)
  • Nucleic Acid Amplification Technology (NAT) for early detection of HIV, HBV, and HCV

Therapeutic Apheresis

  • Plasma exchange for autoimmune, renal, neurological, and metabolic diseases
  • Cascade plasmapheresis for antibody removal in incompatible transplants
  • Immunoadsorption for selective antibody elimination
  • Red cell exchange for sickle cell disease and severe haemoglobinopathies
  • Thrombocytapheresis and leucocytapheresis for blood cell count reduction
  • Extracorporeal photopheresis for GVHD, transplant rejection, and certain cancers
  • LDL apheresis
  • Other therapeutic cell therapy collections

Transplant Immunology

  • HLA typing (low and high resolution)
  • Screening and identification of HLA antibodies
  • Crossmatch testing and chimerism analysis
  • Non-invasive surveillance for graft rejection using cell-free DNA
  • HLA-matched platelet support for refractory cases
  • Chimerism analysis for post-transplant monitoring in BMT recipients 
  • Fetal RhD status for patients with a bad obstetric history 
  • Rare non-HLA antibody screening
  • HLA incompatible transplants: Desensitisation, MFI/crossmatch monitoring, antibody-mediated rejection, transfusion support
  • ABO incompatible transplants: Preconditioning with therapeutic apheresis, titre monitoring, antibody-mediated rejection, transfusion support

     

Peripheral Blood Stem Cell Transplants

  • Donor fitness assessment
  • Desensitisation protocols
  • Graft manipulation
  • Blood component therapy
  • Extracorporeal photopheresis
  • Donor lymphocyte infusion (DLI)
  • Work-up of Passenger Lymphocyte Syndrome

Cellular Therapy

  • Haematopoietic stem cell transplant (HSCT) graft manipulation
  • Platelet biotherapies, including PRP, PRF, and platelet gels for regenerative medicine
  • Bone marrow aspirate concentrate therapies
  • Cryopreservation and bedside infusion of stem cells

Clinical Transfusion and Consultation (OP/IP)

  • Patient blood management and optimisation before surgery
  • Support for alloimmunised individuals, autoimmune haemolytic anaemia, and rare blood groups
  • Management of transfusion reactions and unsatisfactory transfusion responses
  • Transfusion planning for obstetric bleeding and massive transfusions
  • Comprehensive transfusion support for solid organ and stem cell transplants
  • Specialised care for haemoglobinopathies and immunotherapy-associated testing challenges

Referral Testing Centre

  • Advanced immunohematology and molecular blood grouping
  • Platelet serology and HPA typing
  • Specialised antibody and coagulation-related testing (ADAMTS13, Anti-PF4, Anti-H antibody)

Conditions Supported

  • Hematological malignancies requiring HSCT
  • Genetic disorders such as thalassemia and sickle cell disease
  • Severe autoimmune conditions managed with plasma exchange or immunoadsorption
  • Graft rejection and graft-versus-host disease in transplant patients
  • Refractory infections and immune deficiency syndromes
  • Trauma, obstetric emergencies, and massive transfusion requirements

Technologies and Facilities

  • NAT-based donor screening platforms
  • Automated immunohematology analyzers
  • Flow cytometry for cellular characterization
  • High-resolution HLA typing systems
  • Cryopreservation and stem cell banking facilities
  • ROTEM/TEG for precision transfusion guidance
  • Dedicated clean rooms for cellular therapy preparation

Meet Our Expert Medical Team

Patient Testimonials

Frequently Asked Questions

We provide stem cell transplants, platelet biotherapies, regenerative medicine solutions, and advanced therapies such as CAR-T support and extracorporeal photopheresis.

It ensures donor-recipient compatibility, reduces the risk of graft rejection, and provides post-transplant monitoring through advanced molecular and serological testing.

All components undergo strict donor screening, advanced infectious disease testing (CLIA and NAT), and quality control measures, ensuring maximum safety.

Therapeutic apheresis is recommended for patients with autoimmune diseases, blood disorders, and transplant incompatibilities where harmful components must be removed from the blood.

Cell and gene therapy involves using advanced laboratory and clinical techniques to repair, replace, or modify human cells and genes for treating a wide range of diseases.