Dr. Manish Singhal is a distinguished oncologist with over two decades of clinical and academic excellence. He specialises in managing solid organ malignancies, including breast, gastrointestinal, genitourinary, lung, and gynaecological cancers. A DM (Oncology) graduate from AIIMS, New Delhi, he has received advanced training at Oxford University (UK) and the Barbara Ann Karmanos Cancer Centre (USA). Recipient of the Best Exam Award at the ESMO (European Society for Medical Oncology) Examination 2013, where he achieved the top global rank as the first Indian to earn this distinction, Dr. Singhal is widely published and serves on key oncology boards. He is recognised for his evidence-based, patient-centric approach and his leadership in advancing cancer care in India.
Education & Training
Awards & Accomplishments
Area Of Expertise
Membership
Work Experience
Publications
Indian Clinical Practice Guidelines for Laryngeal Cancer 1st Author Indian J Cancer 2020; 57:S19-21
The Urological Society of Indian Guidelines for evaluation and management of Prostate Cancer – Executive Summary. Co Author Indian J Urology 2022; 38:252-257
The future of lung cancer therapy: Striding beyond Conventional EGFR and ALK Treatments Co author Mol Clin Oncol 2019; 10:469
Indian Clinical Practice Guidelines for very advanced squamous cell Cancer of the head and neck Co author Indian J Cancer 2020; 57:S22-25
Practical Consensus recommendation regarding the management of Her 2 posiitve MBC 1st Author South Asia J Cancer 2018; 7:146
First Indian National Conference on Cervical Cancer Management - Expert Recommendations and Identification of Barriers in Implementation Co Author Submitted in International Journal of Gynecological cancer
Indian Clinical Practice Consensus Guidelines for Squamous cell carcinoma of head and neck Co Author Indian J cancer 2020; 57:S1-5
T-cell Prolymphocytic leukemia detected in a patient of breast cancer at the time of recurrence First Author Cases Journal 2010, 3:4 (BM Central)
Transplant in Multiple Myeloma First Author Chapter in Annual book of Haematology Today 2010 (Prof. MB Aggarwal)
Conquering a Complex Brain Aneurysm with Advanced Endovascular Therapy
A patient with a spinal condition was treated at Yashoda Medicity through a navigation-guided minimally invasive spine surgery, marking the first such procedure in the state. The surgery was performed in our state-of-the-art Neuro-Spine OT, equipped with O-arm, Stealth-8 Neuronavigation, Allen table, and IONM.
The procedure was led by Dr. Dibya Jyoti Mahakul, Consultant – Minimally Invasive Neuro-Spine Surgeon, who performed the surgery with unmatched precision. Using the neuronavigation system, the team could visualize the move...
Conquering a Complex Brain Aneurysm with Advanced Endovascular Therapy
A patient with a spinal condition was treated at Yashoda Medicity through a navigation-guided minimally invasive spine surgery, marking the first such procedure in the state. The surgery was performed in our state-of-the-art Neuro-Spine OT, equipped with O-arm, Stealth-8 Neuronavigation, Allen table, and IONM.
The procedure was led by Dr. Dibya Jyoti Mahakul, Consultant – Minimally Invasive Neuro-Spine Surgeon, who performed the surgery with unmatched precision. Using the neuronavigation system, the team could visualize the movements of all instruments in real time, ensuring the accurate placement of implants.
The minimally invasive approach resulted in minimal blood loss and muscle damage, and the patient experienced immediate pain relief. This achievement underscores our commitment to leveraging cutting-edge technology to provide safe, precise, and effective surgical solutions for spine problems.
At Yashoda Medicity, we care about your back. When it comes to spine conditions, you’re in safe hands.
Treatment By:
Dr. Dibya Jyoti Mahakul
First Navigation-Guided Minimally Invasive Spine Surgery at Yashoda Medicity
A patient with a spinal condition was treated at Yashoda Medicity through a navigation-guided minimally invasive spine surgery, marking the first such procedure in the state. The surgery was performed in our state-of-the-art Neuro-Spine OT, equipped with O-arm, Stealth-8 Neuronavigation, Allen table, and IONM.
The procedure was led by Dr. Dibya Jyoti Mahakul, Consultant – Minimally Invasive Neuro-Spine Surgeon, who performed the surgery with unmatched precision. Using the neuronavigation system, the team could visualize the mo...
First Navigation-Guided Minimally Invasive Spine Surgery at Yashoda Medicity
A patient with a spinal condition was treated at Yashoda Medicity through a navigation-guided minimally invasive spine surgery, marking the first such procedure in the state. The surgery was performed in our state-of-the-art Neuro-Spine OT, equipped with O-arm, Stealth-8 Neuronavigation, Allen table, and IONM.
The procedure was led by Dr. Dibya Jyoti Mahakul, Consultant – Minimally Invasive Neuro-Spine Surgeon, who performed the surgery with unmatched precision. Using the neuronavigation system, the team could visualize the movements of all instruments in real time, ensuring the accurate placement of implants.
The minimally invasive approach resulted in minimal blood loss and muscle damage, and the patient experienced immediate pain relief. This achievement underscores our commitment to leveraging cutting-edge technology to provide safe, precise, and effective surgical solutions for spine problems.
At Yashoda Medicity, we care about your back. When it comes to spine conditions, you’re in safe hands.
Treatment By:
Dr. Dibya Jyoti Mahakul
First Awake Brain Surgery at Yashoda Medicity
At Yashoda Medicity, we don’t just operate on brain tumors – we preserve normal brain functions too. We successfully performed our first awake brain surgery in our state-of-the-art Neurosurgery OT, equipped with the Kinevo 900 operating microscope with 3D exoscope, fluorescence filters, Stealth-8 neuronavigation system, BK 5000 intraoperative ultrasound, IONM, and CUSA.
Led by Dr. Dibya Jyoti Mahakul, Consultant - Minimal invasive Brain, Spine and Endovascular Neurosurgery and supported by our expert neuroanaesthesia team and neuropsychologist, t...
First Awake Brain Surgery at Yashoda Medicity
At Yashoda Medicity, we don’t just operate on brain tumors – we preserve normal brain functions too. We successfully performed our first awake brain surgery in our state-of-the-art Neurosurgery OT, equipped with the Kinevo 900 operating microscope with 3D exoscope, fluorescence filters, Stealth-8 neuronavigation system, BK 5000 intraoperative ultrasound, IONM, and CUSA.
Led by Dr. Dibya Jyoti Mahakul, Consultant - Minimal invasive Brain, Spine and Endovascular Neurosurgery and supported by our expert neuroanaesthesia team and neuropsychologist, the patient was kept awake during key parts of the procedure, allowing continuous monitoring of neurological function.
This milestone underscores our commitment to precision-driven, comprehensive care for patients with brain tumors. It reflects our dedication to bringing cutting-edge technology to society and providing safer neurosurgical options, resulting in faster recovery and better outcomes.
When it comes to brain surgeries, you’re in expert hands at Yashoda Medicity.
Treatment By:
Dr. Dibya Jyoti Mahakul
A 4-year-old, 11 kg child was brought to the Department of Pediatric Cardiac Sciences at Yashoda Medicity, Indirapuram, with complaints of bluish discoloration of fingernails and toes, poor weight gain, easy fatigue on walking, and recurrent hospital admissions.
Clinical evaluation revealed an oxygen saturation of 75%, prompting further investigations including echocardiography and CT pulmonary angiography.
The child was diagnosed with Cyanotic Congenital Heart Disease known as Tetralogy of Fallot (TOF), with additional apical muscular VSD and a hypoplastic pulmonary annulus.
The patient underwent open-heart surg...
A 4-year-old, 11 kg child was brought to the Department of Pediatric Cardiac Sciences at Yashoda Medicity, Indirapuram, with complaints of bluish discoloration of fingernails and toes, poor weight gain, easy fatigue on walking, and recurrent hospital admissions.
Clinical evaluation revealed an oxygen saturation of 75%, prompting further investigations including echocardiography and CT pulmonary angiography.
The child was diagnosed with Cyanotic Congenital Heart Disease known as Tetralogy of Fallot (TOF), with additional apical muscular VSD and a hypoplastic pulmonary annulus.
The patient underwent open-heart surgery called Intracardiac Repair, including closure of multiple VSDs with a transannular patch over the neopulmonary valve. The procedure was led by Dr. Abhinavsingh Chauhan, Consultant Pediatric Cardio-thoracic and Vascular Surgery. Advanced post-operative care in the Pediatric Cardiac ICU was uneventful, and post-operative echocardiography confirmed a successful repair.
The child was discharged in a stable and ambulatory condition on the 5th post-operative day, with oxygen saturation improving to 99%. This case reflects Yashoda Medicity’s expertise in managing complex pediatric cardiac conditions, combining cutting-edge surgical techniques with specialized intensive care to ensure safe, life-transforming outcomes for children.
Treatment By:
Dr. Abhinavsingh Chauhan
A challenging Case of renal transplant with a history of >22 units of blood transfusion and class 1 DSA positive
A 26-year-old male was diagnosed with chronic kidney disease after developing generalised weakness and loss of appetite. Investigations revealed impaired renal function with a creatinine of 12 mg/dl and haemoglobin of 5 g/dl. He was started on haemodialysis through a catheter placed in the right side of his neck and advised AV fistula creation with maintenance haemodialysis three times a week.
Despite regular dialysis, his anaemia persisted and he required multiple blood trans...
A challenging Case of renal transplant with a history of >22 units of blood transfusion and class 1 DSA positive
A 26-year-old male was diagnosed with chronic kidney disease after developing generalised weakness and loss of appetite. Investigations revealed impaired renal function with a creatinine of 12 mg/dl and haemoglobin of 5 g/dl. He was started on haemodialysis through a catheter placed in the right side of his neck and advised AV fistula creation with maintenance haemodialysis three times a week.
Despite regular dialysis, his anaemia persisted and he required multiple blood transfusions (more than 22 units over three months) even while receiving erythropoietin and iron therapy. Anaemia workup revealed occult blood in the stool, and upper GI endoscopy confirmed peptic ulcer disease.
He consulted our team of nephrologists (Dr Prajit Mazumdar and Dr Inderjit G. Momin) and urologists (Dr Vaibhav Saxena and Dr Kuldeep Agarwal) at Yashoda Superspeciality Hospitals, Kaushambi, where renal transplantation was advised. His mother, who had a matching blood group, was identified as the donor. However, transplant workup revealed donor-specific antibodies on single antigen bead testing (Class I) with an MFI greater than 2500 on multiple beads, most likely due to the multiple blood transfusions. This significantly increased the risk of acute rejection in the immediate post-transplant period, making the case high-risk.
After thorough counselling regarding risks, he underwent desensitisation with two sessions of plasmapheresis and IVIg to reduce the donor-specific antibodies. He then successfully underwent renal transplantation with ATG induction. Post-transplant, he maintained good urine output with steadily improving creatinine levels and was discharged with a creatinine of 1.2 mg/dl.
He continues to do well on outpatient follow-up.
Treatment By:
Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal
An International patient from Myanmar with Mitral Regurgitation, pulmonary hypertension and low ejection fraction-35% underwent successful transplant
A middle aged male was diagnosed with chronic kidney disease when he developed generalized body weakness, puffiness of face and swelling of legs with nausea, intermittent vomiting . On Investigations, he was found to have deranged renal function with urea-300 mg/dl,creatinine of 15 mg/dl, hb-9 mg and was subsequently started on hemodialysis via catheter inserted in right side of neck.
He subsequently visited India where he consulted our expert tea...
An International patient from Myanmar with Mitral Regurgitation, pulmonary hypertension and low ejection fraction-35% underwent successful transplant
A middle aged male was diagnosed with chronic kidney disease when he developed generalized body weakness, puffiness of face and swelling of legs with nausea, intermittent vomiting . On Investigations, he was found to have deranged renal function with urea-300 mg/dl,creatinine of 15 mg/dl, hb-9 mg and was subsequently started on hemodialysis via catheter inserted in right side of neck.
He subsequently visited India where he consulted our expert team of doctors-Dr Prajit Mazumdar, Dr Inderjit G Momin,Dr Vaibhav Saxena and Dr Kuldeep Agarwal at Yashoda superspeciality Hospital, Kausambi who advised her to under renal transplant as it is the best form of renal replacement therapy. His Transplant workup was subsequently started and donor was wife and blood group was same.
However on transplant work up, it was found that he had Mitral Regurgitation, pulmonary hypertension and low ejection fraction-35% which increased his peri operative risk. Subsequently he was started on medicines and decongestion was done with diuretics and intensive hemodialysis. Subsequently renal transplantation was done after obtaining cardiology clearance with moderate risk and explaining the risk.
He underwent renal transplantation with Solumedrol and ATG induction. After transplantation he had good urine output with decreasing creatinine and was subsequently discharged with creatinine of 1.2 mg/dl . After transplant his pulmonary hypertension decreased and mitral regurgitation decreased which proves renal replacement therapy in form of transplant leads to improvement of cardiac condition. He is doing well on OPD follow up even today, 1.5 year after transplant with stable graft function and enjoying his life in myanmar.
Treatment By:
Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal
A challenging case of Erythroderma in a young male patient.
A 31-year-old male presented to our dermatology OPD with severe redness and flakiness of skin all over the body. The symptoms had been present for two months, with a marked worsening in the last 15 days. After a detailed history, examination, and workup, the patient was diagnosed with Erythroderma – a serious condition where there is erythema and scaling over more than 90% of the body surface area. Despite having experienced similar skin problems in the past, the patient had never received a correct diagnosis and was unaware of the underlying dis...
A challenging case of Erythroderma in a young male patient.
A 31-year-old male presented to our dermatology OPD with severe redness and flakiness of skin all over the body. The symptoms had been present for two months, with a marked worsening in the last 15 days. After a detailed history, examination, and workup, the patient was diagnosed with Erythroderma – a serious condition where there is erythema and scaling over more than 90% of the body surface area. Despite having experienced similar skin problems in the past, the patient had never received a correct diagnosis and was unaware of the underlying disorder that could have led to Erythroderma.
Given the extensive nature of skin involvement and risk of serious complications, he was admitted for detailed evaluation and prompt management. A thorough workup was performed, and appropriate medical treatment was initiated. Over the course of 7–10 days, the patient showed remarkable clinical improvement; the skin lesions resolved significantly, systemic parameters stabilized, and he was safely discharged.
Most importantly, after nearly 3–4 years of recurrent but undiagnosed skin issues, the patient was finally diagnosed with atopic dermatitis. This accurate diagnosis not only explained his longstanding symptoms but also enabled the initiation of targeted treatment and counseling regarding long-term care and preventive measures. With this approach, the patient was able to move beyond temporary symptom relief toward effective disease control and an improved quality of life.
Treatment By:
Dr. Kriti Maheshwari
A 4-year-old male child with congenital Pelvi-Ureteric Junction (PUJ) Obstruction underwent Robot-Assisted Pyeloplasty at Yashoda Medicity. The child had an excellent postoperative recovery and was discharged on postoperative day 2.
Robotic surgery offers superior precision and control, providing a significant advantage not only in cancer surgeries but also in pediatric minimally invasive procedures.
The benefits of robotic surgery over conventional techniques include smaller incisions, minimal intraoperative blood loss, enhanced surgical precision and dissection, reduced postoperative pain, and faster recovery and di...
A 4-year-old male child with congenital Pelvi-Ureteric Junction (PUJ) Obstruction underwent Robot-Assisted Pyeloplasty at Yashoda Medicity. The child had an excellent postoperative recovery and was discharged on postoperative day 2.
Robotic surgery offers superior precision and control, providing a significant advantage not only in cancer surgeries but also in pediatric minimally invasive procedures.
The benefits of robotic surgery over conventional techniques include smaller incisions, minimal intraoperative blood loss, enhanced surgical precision and dissection, reduced postoperative pain, and faster recovery and discharge.
The Department of Urology at Yashoda Medicity is committed to providing the highest standard of care to every patient, with special expertise in Robotic Surgery, Reconstructive Urology, Uro-Oncology, Stone Diseases, and Renal Transplant Surgeries.
Treatment By:
Dr. Vaibhav Saxena
The Department of Urology at Yashoda Medicity, Indirapuram, headed by Dr. Vaibhav Saxena, a pioneer in Robotic Urological Surgeries, has successfully performed a wide range of robotic procedures in both Urology and Uro-Oncology. Patients from across India have been successfully treated for various cancers and other urological conditions.
Among his recent notable cases was a Robotic Radical Cystectomy with Pelvic Lymph Node Dissection and Intracorporeal Urinary Diversion, performed on a patient who had travelled from Mathura for treatment. The patient had previously received neoadjuvant chemoradiation but developed a recurre...
The Department of Urology at Yashoda Medicity, Indirapuram, headed by Dr. Vaibhav Saxena, a pioneer in Robotic Urological Surgeries, has successfully performed a wide range of robotic procedures in both Urology and Uro-Oncology. Patients from across India have been successfully treated for various cancers and other urological conditions.
Among his recent notable cases was a Robotic Radical Cystectomy with Pelvic Lymph Node Dissection and Intracorporeal Urinary Diversion, performed on a patient who had travelled from Mathura for treatment. The patient had previously received neoadjuvant chemoradiation but developed a recurrence in the urinary bladder. Curative robotic surgery was deemed the best option. The patient underwent a successful procedure and was discharged on the fifth postoperative day.
Treatment By:
Dr. Vaibhav Saxena
Total Hip Replacement in a Young Adult with Secondary Osteoarthritis of the Hip due to Sequelae of Childhood Septic Arthritis
Early and effective treatment of childhood hip septic arthritis is crucial to prevent or minimize long-term complications such as avascular necrosis, hip dislocation, osteoarthritis, and leg length discrepancy.
We present a case of a 30-year-old male patient suffering from secondary osteoarthritis of the left hip, with complete destruction of the joint over the past 20 years. He had septic arthritis of the left hip at the age of 9, which was only partially treated, resulting i...
Total Hip Replacement in a Young Adult with Secondary Osteoarthritis of the Hip due to Sequelae of Childhood Septic Arthritis
Early and effective treatment of childhood hip septic arthritis is crucial to prevent or minimize long-term complications such as avascular necrosis, hip dislocation, osteoarthritis, and leg length discrepancy.
We present a case of a 30-year-old male patient suffering from secondary osteoarthritis of the left hip, with complete destruction of the joint over the past 20 years. He had septic arthritis of the left hip at the age of 9, which was only partially treated, resulting in long-term sequelae.
This was a challenging case due to the chronic arthritic hip and associated soft tissue contractures. We performed an uncemented total hip replacement with subtrochanteric osteotomy. The procedure proceeded as planned: the limb length discrepancy was corrected, and the patient was mobilized within 24 hours. He was discharged after four days, pain-free, and walking with support.
He is expected to achieve full weight-bearing and return to all activities of daily living within eight to ten weeks.
Treatment By:
Dr. Amit Sharma
A new life donated to daughter-in law by mother in law
A 30-year-old female was diagnosed with chronic kidney disease after presenting with generalised weakness, loss of appetite, and intermittent vomiting. Investigations revealed impaired renal function, and she was started on haemodialysis through a catheter placed in the right side of her neck. She was advised maintenance haemodialysis three times a week.
She consulted our expert team of doctors including Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal at Yashoda Superspeciality Hospital, Kaushambi. They recomme...
A new life donated to daughter-in law by mother in law
A 30-year-old female was diagnosed with chronic kidney disease after presenting with generalised weakness, loss of appetite, and intermittent vomiting. Investigations revealed impaired renal function, and she was started on haemodialysis through a catheter placed in the right side of her neck. She was advised maintenance haemodialysis three times a week.
She consulted our expert team of doctors including Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal at Yashoda Superspeciality Hospital, Kaushambi. They recommended renal transplantation as the most effective form of renal replacement therapy. Her transplant workup was initiated, with her mother considered as the first donor option.
However, her mother was found to have diabetes, her father had a cardiac condition, and her husband was not a compatible blood group. With limited donor options, her mother-in-law, who had a matching blood group, came forward to donate a kidney and save her daughter-in-law’s life.
After obtaining clearance from cardiology, pulmonology, gynaecology, and psychiatry, along with approval from the authorisation committee, the transplant was successfully carried out with ATG induction. Post-transplant, she maintained good urine output with steadily improving creatinine levels. She was discharged with a creatinine of 1.2 mg/dl. The donor also recovered well and continues to do fine.
Treatment By:
Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal
An International patient from Myanmar with Mitral Regurgitation, pulmonary hypertension, and low ejection fraction-35% underwent successful transplant
A middle-aged male was diagnosed with chronic kidney disease after developing generalised weakness, facial puffiness, swelling of the legs, nausea, and intermittent vomiting. Investigations revealed severely impaired renal function with urea of 300 mg/dl, creatinine of 15 mg/dl, and haemoglobin of 9 g/dl. He was started on haemodialysis through a catheter placed in the right side of his neck.
He later visited India and consulted our expert team of doct...
An International patient from Myanmar with Mitral Regurgitation, pulmonary hypertension, and low ejection fraction-35% underwent successful transplant
A middle-aged male was diagnosed with chronic kidney disease after developing generalised weakness, facial puffiness, swelling of the legs, nausea, and intermittent vomiting. Investigations revealed severely impaired renal function with urea of 300 mg/dl, creatinine of 15 mg/dl, and haemoglobin of 9 g/dl. He was started on haemodialysis through a catheter placed in the right side of his neck.
He later visited India and consulted our expert team of doctors, including Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal at Yashoda Superspeciality Hospital, Kaushambi. Renal transplantation was advised as the most effective form of renal replacement therapy. His transplant workup was initiated, and his wife, who had a matching blood group, volunteered to donate.
During the evaluation, he was found to have mitral regurgitation, pulmonary hypertension, and a reduced ejection fraction of 35 percent, which significantly increased his perioperative risk. He was started on medications, optimised with diuretics, and maintained on intensive haemodialysis for decongestion. After cardiology clearance and counselling regarding moderate surgical risk, renal transplantation was planned.
He successfully underwent renal transplantation with Solumedrol and ATG induction. Post-transplant, he maintained good urine output with steadily decreasing creatinine levels and was discharged with a creatinine of 1.2 mg/dl. His pulmonary hypertension and mitral regurgitation also improved, demonstrating the positive impact of renal transplantation on cardiac function.
He continues to do well on outpatient follow-up, one and a half years after transplant, with stable graft function, and is enjoying a healthy life in Myanmar.
Treatment By:
Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal
A case of ABO incompatible transplant with high ANTI B TITRES
A 37-year-old male was diagnosed with chronic kidney disease three years ago after presenting with frothy urine and hypertension. Initial investigations revealed a serum creatinine of 3 mg/dl. Over the next few years, his kidney function deteriorated, and he was started on maintenance haemodialysis three times a week via an arteriovenous fistula. He was referred to our hospital by a former recipient who had undergone renal transplantation under Dr Prajit Mazumdar. On evaluation by our team of doctors, the need for renal transplantation was expla...
A case of ABO incompatible transplant with high ANTI B TITRES
A 37-year-old male was diagnosed with chronic kidney disease three years ago after presenting with frothy urine and hypertension. Initial investigations revealed a serum creatinine of 3 mg/dl. Over the next few years, his kidney function deteriorated, and he was started on maintenance haemodialysis three times a week via an arteriovenous fistula. He was referred to our hospital by a former recipient who had undergone renal transplantation under Dr Prajit Mazumdar. On evaluation by our team of doctors, the need for renal transplantation was explained in view of end-stage renal disease.
His transplant workup was initiated, with his father considered as the first donor. However, he was rejected due to diabetes. Donor evaluation of his mother was then undertaken, but her blood group was incompatible with the recipient. In view of ABO incompatibility, anti-A and anti-B titres were assessed and revealed a high anti-B titre.
After detailed counselling regarding prognosis, risks, and cost, the family opted to proceed with an ABO-incompatible renal transplant. Rituximab was administered two weeks prior to transplantation, and he was started on tacrolimus and mycophenolate mofetil. This was followed by two sessions of Glycosorb column treatment on days 12 and 14, after which his anti-B titre decreased to 1:2. He then underwent renal transplantation with Solumedrol and Simulect induction, with anti-B titres monitored every 12 hours.
Post-transplant, he maintained brisk urine output and his serum creatinine gradually declined. He was discharged with a creatinine of 1.2 mg/dl and continues to do well on follow-up.
Treatment By:
Dr Prajit Mazumdar
A challenging Case of renal transplant with a history of >22 units of blood transfusion and class 1 DSA positive
A 26-year-old male was diagnosed with chronic kidney disease after developing generalised weakness and loss of appetite. Investigations revealed impaired renal function with a creatinine of 12 mg/dl and haemoglobin of 5 g/dl. He was started on haemodialysis through a catheter placed in the right side of his neck and advised AV fistula creation with maintenance haemodialysis three times a week.
Despite regular dialysis, his anaemia persisted and he required multiple blood transfusions (more...
A challenging Case of renal transplant with a history of >22 units of blood transfusion and class 1 DSA positive
A 26-year-old male was diagnosed with chronic kidney disease after developing generalised weakness and loss of appetite. Investigations revealed impaired renal function with a creatinine of 12 mg/dl and haemoglobin of 5 g/dl. He was started on haemodialysis through a catheter placed in the right side of his neck and advised AV fistula creation with maintenance haemodialysis three times a week.
Despite regular dialysis, his anaemia persisted and he required multiple blood transfusions (more than 22 units over three months) even while receiving erythropoietin and iron therapy. Anaemia workup revealed occult blood in the stool, and upper GI endoscopy confirmed peptic ulcer disease.
He consulted our team of nephrologists (Dr Prajit Mazumdar and Dr Inderjit G. Momin) and urologists (Dr Vaibhav Saxena and Dr Kuldeep Agarwal) at Yashoda Superspeciality Hospitals, Kaushambi, where renal transplantation was advised. His mother, who had a matching blood group, was identified as the donor. However, transplant workup revealed donor-specific antibodies on single antigen bead testing (Class I) with an MFI greater than 2500 on multiple beads, most likely due to the multiple blood transfusions. This significantly increased the risk of acute rejection in the immediate post-transplant period, making the case high-risk.
After thorough counselling regarding risks, he underwent desensitisation with two sessions of plasmapheresis and IVIg to reduce the donor-specific antibodies. He then successfully underwent renal transplantation with ATG induction. Post-transplant, he maintained good urine output with steadily improving creatinine levels and was discharged with a creatinine of 1.2 mg/dl.
He continues to do well on outpatient follow-up.
Treatment By:
Dr Prajit Mazumdar, Dr Inderjit G. Momin, Dr Vaibhav Saxena, and Dr Kuldeep Agarwal
Conquering a Complex Brain Aneurysm with Advanced Endovascular Therapy
Brain aneurysms are often described as ticking time bombs—silent, unpredictable, and potentially life-threatening if left untreated. They pose one of the most complex challenges in modern neurosurgery, requiring both precision and cutting-edge technology for successful management.
A 60-year-old woman presented with multiple episodes of severe headache, prompting her to consult Dr. Sumantao Chaterjee (Neurologist). Given the persistence and pattern of her symptoms, a brain angiography was recommended and performed by Dr. ...
Conquering a Complex Brain Aneurysm with Advanced Endovascular Therapy
Brain aneurysms are often described as ticking time bombs—silent, unpredictable, and potentially life-threatening if left untreated. They pose one of the most complex challenges in modern neurosurgery, requiring both precision and cutting-edge technology for successful management.
A 60-year-old woman presented with multiple episodes of severe headache, prompting her to consult Dr. Sumantao Chaterjee (Neurologist). Given the persistence and pattern of her symptoms, a brain angiography was recommended and performed by Dr. Dibya Jyoti Mahakul (Endovascular Neurosurgeon).
The imaging revealed a complex brain aneurysm, one that demanded meticulous planning due to its size, shape, location, and blood flow dynamics. After careful evaluation, the patient was offered a scarless, minimally invasive endovascular treatment. A flow diverter stent was strategically placed across the neck of the aneurysm to divert blood flow away from the aneurysm sac, promoting healing and preventing rupture. While technically challenging, the procedure was greatly aided by our state-of-the-art biplanar cath lab, equipped with advanced imaging tools like Vaso CT, CBCT, and MAFA software. These technologies ensured maximum precision, safety, and speed for both the patient and surgical team. Remarkably, the patient was discharged the very next day in a stable condition—aneurysm secured, risk averted.
Today, she is back home with her family, free from the shadow of a life-threatening condition, and ready to embrace life on her own terms.
Treatment By:
Dr. Dibya Jyoti Mahakul, Dr. Sumantao Chaterjee
A 51-year-old lady with left arm pain more than neck pain of 10 years duration, with BMI 44 and a short neck nearly the chin touching the chest, was diagnosed with OPLL C3-6 with myelopathy and fixed kyphosis of 20°. MRI showed cord signal changes at C5, and CT confirmed OPLL C3 -6 with high probability of intradural mass ( double density sign). Conventional wisdom (K line, kyphosis, anterior pathology etc.) dictated towards an anterior surgery, but possibility of dural laceration (intradural OPLL mass), with potential for other complications (cord / trachea / esophageal compression by pseudomeningole, meningitis, spinal cord ...
A 51-year-old lady with left arm pain more than neck pain of 10 years duration, with BMI 44 and a short neck nearly the chin touching the chest, was diagnosed with OPLL C3-6 with myelopathy and fixed kyphosis of 20°. MRI showed cord signal changes at C5, and CT confirmed OPLL C3 -6 with high probability of intradural mass ( double density sign). Conventional wisdom (K line, kyphosis, anterior pathology etc.) dictated towards an anterior surgery, but possibility of dural laceration (intradural OPLL mass), with potential for other complications (cord / trachea / esophageal compression by pseudomeningole, meningitis, spinal cord hernia etc.) were discussed in detail and a decission was taken to decompress and fix from the posterior aspect. The pre-op CT angio showed B/L high-riding vertebral arteries, which precluded the C2 screw.
Per operatively, the patient was positioned prone with the head clamped and a posterior exposure done. LM screw entry points were made from C3-6, followed by grade 1 facet resection at C3-4, C4-5, and C5-6 bilaterally. Further lordosis was achieved with manipulation of the head with the head clamp and closing the osteotomy gaps. LM screws (C3-6), a laminar screw at C2, and a pedicle screw at T1 & 2 were inserted and connected with rods.
C3-6 laminectomy was done, and the surgical site was closed after bone graft mixed with vancomycin was applied laterally.
Postoperative x-ray showed adequate lordosis (approximately 10 degrees) attainment.
The patient reported complete pain relief in the left shoulder and arm postoperatively.
Treatment By:
Dr. Ankur Goswami
A tremendous job has been done by Dr. Amit Sharma. I met with an accident in which the ACL ligament of my left knee was completely torn. I met Dr. Amit Sharma then he analysed the situation and told us about the procedure and the time period to recover from the injury. He has performed a successful surgery. The good thing is the confidence that Dr. Amit Sharma has on his surgery that he didn’t put braces on the knee while other doctors put the braces on for a month and then started Physiotherapy which will take a longer time period to heal from the injury.
Dr. Amit Sharma has started the Physiotherapy from the very next day of the surgery and i was discharged in 2 days, and the Physiotherapy is undergoing at my home. It's the 10th day today and I have gained so much confidence in 10 days that I am recovering very fast and in a few weeks I will be able to walk without any support.
Thanks to Dr. Amit Sharma, he is really having magical hands, he is very kind in nature, in my regular visits all of my stress went away after talking to him.
Again Thank You so much Doctor
Treatment By:
Dr. Amit Sharma
Finally successful operation of father disease Lipoma has been done. Thanks a lot to Dr. Asheesh, Dr. Govind and Dr. Arindam Mukherjee, Nurses along with all staff. Nice experience, overall I can say every service of this hospital is outstanding.
Our heartfelt thanks to the entire Hospital, especially Dr Aayush Goyal and his team who performed the CABG surgery on our patient (Sh Arvind Bhatia) with extremely satisfactory results. Personal attention given to our case by the hospital COO, Dr. Sunil Dagar and the total management and the hospital staff, who ensured we were given utmost priority in all respects during the course of the treatment. Special thanks to Dr Asit Khanna for his diagnosis and guidance. Last but not the least, the homecare services provided by the hospital were really good.
Excellent services
Outstanding Results
We wish all the best to the hospital and its team.
