Overview of Specialty

The Bone Marrow Transplant (BMT) Department at Yashoda Medicity is dedicated to delivering advanced, comprehensive care for patients with life-threatening blood, immune, and genetic disorders. Bone marrow and stem cell transplantation is a highly specialized treatment that replaces diseased or damaged bone marrow with healthy stem cells, enabling patients to rebuild normal blood and immune function.

With advanced facilities, a dedicated transplant unit, and infection-controlled environments, our program is designed to ensure maximum safety and success. From pre-transplant evaluation to long-term survivorship care, we provide holistic, compassionate treatment that extends beyond clinical protocols to include psychological, nutritional, and rehabilitative support.

Conditions Managed

The BMT Department offers treatment for a wide range of malignant and non-malignant conditions, including:

  • Leukemias: Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myeloid Leukemia (CML)
  • Lymphomas: Hodgkin’s and Non-Hodgkin’s Lymphoma
  • Multiple Myeloma and Plasma Cell Disorders
  • Bone Marrow Failure Syndromes: Aplastic Anemia, Myelodysplastic Syndromes (MDS)
  • Inherited Blood Disorders: Thalassemia Major, Sickle Cell Disease
  • Immunodeficiency Disorders: Severe Combined Immunodeficiency (SCID), Primary Immune Deficiencies
  • Metabolic and Genetic Disorders: Storage disorders such as Gaucher’s and Hurler’s Syndrome

Types of Bone Marrow Transplant

  • Autologous Transplant
    The patient’s own stem cells are collected, stored, and reinfused after high-dose chemotherapy. This is commonly used for multiple myeloma, lymphomas, and some solid tumors.
  • Allogeneic Transplant
    Healthy stem cells are taken from a matched donor (sibling, relative, or unrelated donor). This approach is used for leukemias, aplastic anemia, and genetic blood disorders.
  • Matched Related Donor (MRD) Transplant
    Stem cells are donated by a fully HLA-matched sibling or family member.
  • Matched Unrelated Donor (MUD) Transplant
    Stem cells are obtained from international donor registries when a family match is unavailable.
  • Haploidentical (Half-Matched) Transplant
    Stem cells are transplanted from parents or children who are a 50% genetic match, increasing donor availability.
  • Umbilical Cord Blood Transplant
    Stem cells derived from cord blood are used for patients without a suitable donor.

Facilities and Infrastructure

  • Dedicated Laminar Airflow Transplant Units with HEPA filtration and infection-control systems
  • Advanced Apheresis and Stem Cell Processing Laboratory
  • Facilities for cryopreservation of stem cells
  • 24×7 availability of blood bank and transfusion medicine
  • Multidisciplinary team including oncologists, hematologists, immunologists, infectious disease experts, dieticians, and psychologists
  • Comprehensive post-transplant monitoring and rehabilitation programs

Treatment Process

  1. Pre-Transplant Evaluation
    • Complete diagnostic work-up including imaging, molecular studies, HLA typing, and infection screening
    • Nutritional and psychological counseling
    • Donor evaluation (for allogeneic procedures)
  2. Conditioning Therapy
    • High-dose chemotherapy, with or without radiation, to eradicate diseased cells and prepare bone marrow for new stem cells
  3. Stem Cell Infusion
    • Healthy stem cells are infused intravenously, similar to a blood transfusion
  4. Engraftment and Recovery
    • New stem cells start producing blood cells; patients are closely monitored for infections, bleeding, and organ functions
  5. Post-Transplant Care
    • Management of complications like graft-versus-host disease (GVHD), infections, and metabolic issues
    • Long-term follow-up for relapse monitoring, immune recovery, and quality of life improvement
       

Patient Testimonials

Frequently Asked Questions

A bone marrow transplant is a medical procedure that replaces diseased or damaged bone marrow with healthy stem cells to restore normal blood and immune function.

Recovery varies depending on transplant type and patient condition but generally takes 3–6 months, with lifelong monitoring.

No. If a matched family donor is unavailable, unrelated donors, haploidentical family members, or cord blood units can be used.

Risks include infections, graft-versus-host disease (GVHD), bleeding, and relapse. With improved supportive care, success rates have significantly increased.

Yes. BMT is often a life-saving option for pediatric patients with thalassemia, sickle cell disease, immunodeficiencies, or leukemias.